From the historic Mission District, rooted in deep Mexican heritage, to the city's modern craft cocktail bars, San Francisco honors mezcal both as an ancient tradition and as a symbol of creativity. Artisanal mezcalerías, agave-focused events, and a thriving community of spirit lovers have made mezcal an essential part of the city's dynamic culinary landscape.Like the resilient agave plant, San Francisco has always thrived on transformation, authenticity, and bold character. Here, every sip of mezcal tells a story — one of heritage, artistry, and the enduring quest for connection and discovery.